On March 1, 2012, Bartolozzi, Alessandra; Bosanac, Todd; Chen, Zhidong; De Lombaert, Stephane; Dines, Jonathon Alan; Huber, John D.; Liu, Weimin; Lo, Ho Yin; Loke, Pui Leng; Morwick, Tina Marie; Nemoto, Peter Allen; Olague, Alan; Riether, Doris; Tye, Heather; Wu, Lifen; Zindell, Renee M. published a patent.Related Products of 62640-03-3 The title of the patent was Preparation of oxadiazole inhibitors of leukotriene production. And the patent contained the following:
The present invention relates to compound I [R1 and R2 together with the carbon atom to which they are attached form (un)substituted carbocyclic ring or 5-11 membered heterocyclic ring; R3 = (un)substituted 5-11 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S; R4 = H, halo, alkyl, nitrile; R5 = (un)substituted alkyl, cycloalkyl, 5-11 membered heterocyclyl, etc.] and pharmaceutically acceptable salt thereof. Over three-hundred compounds I were prepared E.g., a multi-step synthesis of II, starting from the nitrile III and 1,3-dibromopropane, was described. Representative compounds I showed activity in the FLAP binding assay and in the human whole blood LTB4 production inhibition assay (IC50 values were given). The invention also relates to pharmaceutical compositions comprising compounds I, methods of using I in the treatment of various diseases and disorders, processes for preparing I and intermediates useful in these processes. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Related Products of 62640-03-3
The Article related to oxadiazole preparation leukotriene ltb4 production flap inhibitor antitumor antiinflammatory, cardiovascular allergy pulmonary renal disease fibrosis treatment oxadiazole preparation and other aspects.Related Products of 62640-03-3
Referemce:
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