Application of 2854-16-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.
[00274j THF (290 mL), 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)- pyridin-4-yl)-i,3,5-triazin-2-amine (29.0 g, 0.06893 mol), sodium bicarbonate (8.68 g, 0.1033 mol), and 1,1-dimethylaminoethanol (7.37 g, 0.0827 1 mol) are added to the reaction vessel at 20?35 ¡ãC. The resulting slurry is heated to reflux (75-80 ¡ãC) for 16-20 h. The reaction is cooled to 30-40 ¡ãC and THF evaporated at below 45 ¡ãC under reduced pressure. The reaction mixture is cooled to 20?35 ¡ãC and rinsed with ethyl acetate and water, and the ethyl acetate layer collected. The organic layer is concentrated under vacuum at below 45 ¡ãC then rinsed with dichloromethane and hexanes, filtered and washed with hexanes and dried for 8-iOh at 45-50 ¡ãC under vacuum to provide 2-methyl-i -(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)- pyridin-4-ylamino)- 1,3,5 -triazin-2-ylamino)propan-2-ol.
According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; AGRESTA, Samuel, V.; (135 pag.)WO2016/53850; (2016); A1;,
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