Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-50-7, blongs to alcohols-buliding-blocks compound. 623-50-7
To a solution of compound 1 (200 g, 1.92 mol) in DCM (dichloromethane, 2L) was added TBDPSi-CI (tert-butyldiphenylsilyl chloride, 527 g, 1 .92 mol) and the mixture was stirred at room temperature for 20 min untill it dissolved. Then imidazole (261.9 g, 3.85 mol) was added portionwise over 20 min. The resulting mixture was stirred at room temperature for 5 h. To the mixture was added sat.NFUCI (2L), and the aqueous layer extracted with DCM. The combined organics were washed with brine, dried over anhydrous Na2SC”4 and concentrated in vacuum. The resulting crude product was purified by silica-gel column (petroleum ether:acetic acid ethyl ester (PE:AcOEt = 80:1 ) to give 300 g of compound 2 (yield 47.6%). H-NMR (CDCIs): delta= 7.68-7.70 (m, 4H), 7.26-7.43 (m, 6H), 4.23 (s, 2H), 4.14 (q, J= 6.8 Hz, 2H), 1 .22 (t, J= 6.8 Hz, 3H), 1 .09 (s, 9H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-50-7, its application will become more common.
Reference:
Patent; BASF SE; MICHROWSKA-PIANOWSKA, Anna, Aleksandra; KORDES, Markus; HUTZLER, Johannes; NEWTON, Trevor, William; EVANS, Richard, Roger; KREUZ, Klaus; GROSSMANN, Klaus; SEITZ, Thomas; KLOET, Andree van der; WITSCHEL, Matthias; PARRA RAPADO, Liliana; LERCHL, Jens; WO2013/104561; (2013); A1;,
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