In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 1-Amino-2-methylpropan-2-ol
General procedure: A suspension of 26c (2.00 g, 5.47 mmol), 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride (2.27 g, 8.21 mmol) and 1-amino-2-methylpropan-2-ol (0.585 g, 6.56 mmol) in THF (25 mL) and 2-propanol (25 mL) was stirred at room temperature for 19 h. The mixture was concentrated in vacuo, acidified with 1 N HCl, and extracted twice with EtOAc. The organic layers were combined, washed with saturated aqueous solution of NH4Cl and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane-EtOAc). The product was recrystallized from hexane-EtOAc to give 28h (2.06 g, 89percent) as a white solid.
The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yamamoto, Satoshi; Tomita, Naoki; Suzuki, Yuri; Suzaki, Tomohiko; Kaku, Tomohiro; Hara, Takahito; Yamaoka, Masuo; Kanzaki, Naoyuki; Hasuoka, Atsushi; Baba, Atsuo; Ito, Mitsuhiro; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2338 – 2352;,
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