Seguido, Miguel Angel; Tarradas, Rosa Maria; Gonzalez-Ramila, Susana; Garcia-Cordero, Joaquin; Sarria, Beatriz; Bravo-Clemente, Laura; Mateos, Raquel published an article in 2022, the title of the article was Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects.Related Products of 621-37-4 And the article contains the following content:
Knowledge on the bioavailability of coffee (poly)phenols mostly come from single dose postprandial studies. This study aimed at investigating the effects of regularly consuming a green coffee phenolic extract (GCPE) on the bioavailability and metabolism of (poly)phenols. Volunteers with overweight/obesity consumed a decaffeinated GCPE nutraceutical containing 300 mg hydroxycinnamates twice daily for two months. Plasma and urinary pharmacokinetics, and fecal excretion of phenolic metabolites were characterized by LC-MS-QToF at weeks 0 and 8. Fifty-four metabolites were identified in biol. fluids. Regular consumption of the nutraceutical produced certain changes: reduced forms of caffeic, ferulic and coumaric acids in urine or 3-(3′-hydroxypenyl)propanoic, and 3,4-dihydroxybenzoic acids in feces significantly increased (p < 0.05) after 8 wk; in contrast, coumaroylquinic and dihydrocoumaroylquinic acids in urine decreased (p < 0.05) compared to baseline excretion. The sum of intestinal and colonic metabolites increased after sustained consumption of GCPE, without reaching statistical significance, suggesting a small overall effect on (poly)phenols′ bioavailability. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4
The Article related to green coffee nutraceutical consumption phenolic metabolism bioavailability overweight obesity, bioavailability, biotransformation pathways, green coffee, hydroxycinnamates, microbial catabolites, pharmacokinetics and other aspects.Related Products of 621-37-4
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