Nair, Reshma V. R.; Jayasree, Devi Velayudhan; Biju, Prabath Gopalakrishnan; Baby, Sabulal published an article in 2020, the title of the article was Anti-inflammatory and anticancer activities of erythrodiol-3-acetate and 2,4-di-tert-butylphenol isolated from Humboldtia unijuga.Formula: C14H22O And the article contains the following content:
Humboldtia unijuga Bedd., endemic to Agasthyamala in Western Ghats in India, is traditionally used by local Kani tribes for chicken pox, head ache and snake bite. This study reports the isolation of erythrodiol-3-acetate (HU-1) and 2,4-di-tert-butylphenol (HU-2) from H. unijuga roots and their anti-inflammatory and anticancer activities in macrophage, skin and breast cancer cell lines. Effects of HU-1 and HU-2 treatments (50, 100μg/mL) on gene expression profiles of pro-inflammatory cytokines TNFα, IL-6 and IL-1β, and apoptosis genes p53 and caspase 7 were studied. HU-2 exerted a significantly superior anti-inflammatory effect compared to HU-1 in all three pro-inflammatory genes. HU-2 showed a superior dose dependent anticancer effect through activation of p53 gene over HU-1 in MCF-7 cells. HU-1 exhibited a dose dependent effect on caspase 7 gene in both cell lines while HU-2 was more effective in A431. HU-2 has potential for development as a novel anti-inflammatory and anticancer agent. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O
The Article related to humboldtia unijuga erythrodiol acetate ditertbutylphenol antiinflammatory anticancer activity apoptosis, humboldtia unijuga , 2,4-di-tert-butylphenol, anti-inflammatory activity, anticancer activity, apoptosis, erythrodiol-3-acetate and other aspects.Formula: C14H22O
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