On April 30, 2020, Zabela, Volha; Sampath, Chethan; Oufir, Mouhssin; Butterweck, Veronika; Hamburger, Matthias published an article.SDS of cas: 621-37-4 The title of the article was Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats. And the article contained the following:
3,4-Dihydroxyphenylacetic acid (DOPAC) and 3-hydroxyphenylacetic acid (3-HPAA) are intestinal metabolites of the dietary flavonoid quercetin. DOPAC reportedly showed anxiolytic activity after i.p. administration in rats. The fate of these metabolites after consumption, and the pharmacol. properties of 3-HPAA in the body are largely unknown. The aim of the current study was to characterize pharmacokinetic properties of DOPAC and 3-HPAA after i.v. bolus application in rats. UHPLC-MS/MS methods for quantification of DOPAC and 3-HPAA levels in lithium heparin Sprague Dawley rat plasma were developed and validated according to international regulatory guidelines. Non-compartmental and compartmental analyses were performed. Pharmacokinetic profiles of DOPAC and 3-HPAA followed a two-compartment body model, with a fast distribution into peripheral tissues (half-lives of 3.27-5.26 min) and rapid elimination from the body (half-lives of 18.4-33.3 min). The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4
The Article related to pharmacokinetics dihydroxyphenylacetic hydroxyphenylacetic acid uhplc msms, 3,4-dihydroxyphenylacetic acid (pubchem cid: 547), 3-hpaa, 3-hydroxyphenylacetic acid (pubchem cid: 12122)., dopac, pharmacokinetics, uhplc-ms/ms, validation and other aspects.SDS of cas: 621-37-4
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