On April 30, 2021, Velikorodov, A. V.; Stepkina, N. N.; Osipova, V. P.; Zukhairaeva, A. S.; Shustova, E. A. published an article.HPLC of Formula: 96-76-4 The title of the article was Synthesis of New Functionally Substituted Indenes, Benzofurans and 2,5-Benzodiazocin-1(2H)-ones. And the article contained the following:
The synthesis of new functionally substituted 1H-indene-1,3(2H)-diones, such as I [R = pyridin-2-yl, morpholin-4-yl] indenobenzofurans II [R1 = 1-adamantyl, t-Bu; R2 = Me, t-Bu] and 2,5-benzodiazocines III [R3 = H, t-Bu, NHCO2Me, 1-adamantyl; R4 = H, NHCO2Me; R5 = H, Me, t-Bu, NHCO2Me] was described. The condensations of ninhydrin in concentrated sulfuric acid with 2-(morpholin-4-yl)ethyl and 2-(pyridin-2-yl)ethyl phenylcarbamates at 20°C and with 2,6-di-tert-butylphenol while gradually raising temperature from 0 to 20°C gave corresponding 2,2-disubstituted 1H-indene-1,3(2H)-diones such as I in 62-89% yields. The indeno[1,2-b]benzofuran derivatives II were obtained with high yields (96-98%) by heating ninhydrin with 2-(1-adamantyl)-4-methylphenol and 2,4-di(tert-butyl)phenol, resp., in glacial acetic acid at 60°C. Benzofurans containing an adamantyl, tert-Bu, or carbamate fragment reacted with 99% ethylenediamine at 20°C to afford 80-85% of new 2,5-benzodiazocine derivatives III. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4
The Article related to disubstituted indene dione preparation, phenylcarbamate ninhydrin sulfuric acid condensation, indenobenzofuran preparation, ninhydrin phenol acetic acid condensation, benzodiazocine preparation, ethylenediamine indenobenzofuran condensation and other aspects.HPLC of Formula: 96-76-4
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