On April 15, 2010, Etoga, Jean-Louis G.; Ahmed, S. Kaleem; Patel, Sarjubhai; Bridges, Richard J.; Thompson, Charles M. published an article.Recommanded Product: 32462-30-9 The title of the article was Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system Xc- over the vesicular glutamate transporter. And the article contained the following:
A panel of amino acid analogs and conformationally-restricted amino acids bearing a sulfonic acid were synthesized and tested for their ability to preferentially inhibit the obligate cysteine-glutamate transporter system X-c vs. the vesicular glutamate transporter (VGLUT). Several promising candidate mols. were identified: R/S-4-[4′-carboxyphenyl]-phenylglycine, a biphenyl substituted analog of 4-carboxyphenylglycine and 2-thiopheneglycine-5-sulfonic acid both of which reduced glutamate uptake at system X-c – by 70-75% while having modest to no effect on glutamate uptake at VGLUT. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: 32462-30-9
The Article related to glutamate uptake vglut inhibitor amino acid preparation, vesicular glutamate transporter inhibiting structure activity amino acid, phenylglycine aminothiophene sulfonic acid analog preparation, amino acid hydrolysis sulfonation sulfuric acid and other aspects.Recommanded Product: 32462-30-9
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