On October 11, 1983, Ong, Helen H.; Anderson, Vernon B.; Profitt, James A. published a patent.HPLC of Formula: 72364-46-6 The title of the patent was Antidepressive and tranquilizing substituted 1,3-dihydrospiro(benzo[c]thiophene)s. And the patent contained the following:
Title compounds I [R = H, (un)substituted alkyl, alkenyl; R1-R3 = H, alkyl, alkoxy, F3C, Cl, Br, F, HO, alkylthio; R1R2, R2R3 = OCH2O; R4 = (un)substituted Ph; n, n1 = 1-3, n + n1 = 3 or 4] were prepared Thus 2-BrC6H4F was lithiated and treated with N-methylpiperidone II (R5R6 = O) to give II (R5 = OH, R6 = C6H4F-2). The last was treated with PhCH2SH, giving II (R5 = SCH2Ph, R6 = C6H4F-2) which was cyclized to give spiro(benzo[c]thiophene-1,4′-piperidine) III (R7 = Ph). At 50 mg/kg i.p. in mice, III (R7 = C6H4Me-4) had anticholinergic activity, giving 40% survival following i.p. injection with 2.5 mL/kg physostigmine sulfate. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).HPLC of Formula: 72364-46-6
The Article related to spirobenzothiophenepiperidine preparation anticholinergic antidepressant tranquilizer, benzothiophenepiperidine spiro anticholinergic preparation, thiophenepiperidine spirobenzo anticholinergic preparation, piperidine spirobenzothiophene anticholinergic preparation and other aspects.HPLC of Formula: 72364-46-6
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