On March 29, 2021, Zhao, Xiao-Jing; Li, Zi-Hao; Ding, Tong-Mei; Tian, Jin-Miao; Tu, Yong-Qiang; Wang, Ai-Fang; Xie, Yu-Yang published an article.Recommanded Product: (R)-2-Amino-2-(m-tolyl)ethanol The title of the article was Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling. And the article contained the following:
A challenging direct asym. catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96% ee) and good yields (up to 80%). The DFT calculations suggest that the F-H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π-π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).Recommanded Product: (R)-2-Amino-2-(m-tolyl)ethanol
The Article related to amino hydroxy binaphthyl enantioselective synthesis coupling naphthylamine naphthol, copper catalyzed aerobic oxidative cross coupling naphthylamine naphthol, 3,3′- disubstituted nobins, asymmetric catalysis, cross-coupling, enantioselectivity, mechanism investigation and other aspects.Recommanded Product: (R)-2-Amino-2-(m-tolyl)ethanol
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