Safety of tert-Butyl 3-hydroxyazetidine-1-carboxylate, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 141699-55-0, name is tert-Butyl 3-hydroxyazetidine-1-carboxylate, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.
Zhang, Xuejun;Sheng, Xijun;Shen, Jie;Zhang, Shoubo;Sun, Wenjie;Shen, Chunli;Li, Yi;Wang, Jun;Lv, Huqiang;Cui, Minghui;Zhu, Yuchuan;Huang, Lei;Hao, Dongling;Qi, Zhibo;Sun, Guanglong;Mao, Weifeng;Pan, Yan;Shen, Liang;Li, Xin;Hu, Guoping;Gong, Zhen;Han, Shuhua;Li, Jian;Chen, Shuhui;Tu, Ronghua;Wang, Xuehai;Wu, Chengde research published 《 Discovery and Evaluation of Pyrazolo[3,4-d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor》, the research content is summarized as follows. The identification and lead optimization of a series of pyrazolo[3,4-d]pyridazinone derivatives are described as a novel class of potent irreversible BTK inhibitors, resulting in the discovery of compound 8. Compound 8 exhibited high potency against BTK kinase and acceptable PK profile. Furthermore, compound 8 demonstrated significant in vivo efficacy in a mouse-collagen-induced arthritis (CIA) model.
Safety of tert-Butyl 3-hydroxyazetidine-1-carboxylate, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts