With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Formula: C3H6O2
Wuitschik, Georg;Carreira, Erick M.;Wagner, Bjorn;Fischer, Holger;Parrilla, Isabelle;Schuler, Franz;Rogers-Evans, Mark;Muller, Klaus research published 《 Oxetanes in Drug Discovery: Structural and Synthetic Insights》, the research content is summarized as follows. The use of oxetanes as replacements for gem-di-Me or carbonyl groups and their effects on the aqueous solubility, lipophilicity, metabolic stability, and conformation for various compounds are studied; methods for the preparation of a variety of substituted oxetanes are given. The magnitude of changes in properties and in metabolic stability with oxetane substitution depends on the structural context; for example, substitution of a gem-di-Me group with an oxetane, aqueous solubility may increase by a factor of 4 to more than 4000 while reducing the rate of metabolic degradation in most cases. Incorporation of an oxetane into an aliphatic chain increases in some cases the preference for synclinal conformations rather than antiplanar conformations of the chain. Spirocyclic oxetanes such as an oxazaspiroheptane resemble commonly used fragments in drug discovery, such as morpholines, and in some cases increase aqueous solubility more effectively than morpholines. An improved chemoselective oxidation of 3-oxetanol to 3-oxetanone is disclosed; olefination of 3-oxetanone by a variety of methods yields alkylideneoxetanes I [R = (EtO)2P(:O), OHC, O2N, EtO2C, NC, PhO2S, MeCO, 1-(4-chlorophenyl)-1-cyclobutanecarbonyl]. I (R = EtO2C, OHC, O2N) undergo addition reactions with nucleophiles such as amines, carbonyl compounds, and arylboronic acids to give oxetanes such as II. The crystal structures of a variety of oxetanes are determined
7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Formula: C3H6O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts