Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
Example 149E (20 mg, 0.06 mmol) and 2-(3-fiuorophenyl)ethanol (9.3 mg, 0.066 mmol) were dissolved in 1 mL tetrahydrofuran. To this, PS-triphenylphosphine (58 mg, 0.18 mmol, 3.1 mmol/g) was added followed by di-tert-buty azodicarboxylate (20.9 mg, 0.09 mmol). The mixture was stirred at room temperature overnight. The resulting mixture was filtered, concentrated and purified by flash chromatography (0-50% ethyl acetate in hexane). To the material thus obtained was added 0.5 mL 4 MEtaC1 in dioxane. The reaction was stirred at 50 0C until completion. The mixture was concentrated to give the title compound as the hydrochloride salt. 1H NMR (500 MHz, DMSO-J6) delta ppm 9.44 (br, IH), 9.07 (br, 2H), 7.36 (dd, J = 14.4, 7.9 Hz, IH), 7.18 (t, J = 8.0 Hz, 2H), 7.05 (td, J = 8.8, 2.4 Hz, IH), 6.87 (d, J = 8.6 Hz, IH), 6.70 – 6.54 (m, 2H), 4.26 – 4.08 (m, 2H), 3.59 – 3.47 (m, IH), 3.30 (m, 4H), 3.11 – 2.85 (m, 4H), 2.60 (dd, J = 13.4, 7.0 Hz, IH), 1.97 (d, J = 13.5 Hz, IH).
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Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH &; CO. KG; WANG, Ying; BREWER, Jason, T.; AKRITOPOULOU-ZANZE, Irini; DJURIC, Stevan, W.; POHLKI, Frauke; BRAJE, Wilfried; RELO, Ana-Lucia; WO2010/124042; (2010); A2;,
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