In general, the hydroxyl group makes alcohols polar. 7748-36-9, formula is C3H6O2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Reference of 7748-36-9
Nordqvist, Anneli;O’Mahony, Gavin;Friden-Saxin, Maria;Fredenwall, Marlene;Hogner, Anders;Granberg, Kenneth L.;Aagaard, Anna;Baeckstroem, Stefan;Gunnarsson, Anders;Kaminski, Tim;Xue, Yafeng;Dellsen, Anita;Hansson, Eva;Hansson, Pia;Ivarsson, Ida;Karlsson, Ulla;Bamberg, Krister;Hermansson, Majlis;Georgsson, Jennie;Lindmark, Bo;Edman, Karl research published 《 Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity》, the research content is summarized as follows. The mineralocorticoid receptor (MR) is a nuclear hormone receptor involved in the regulation of body fluid and electrolyte homeostasis. In this study we explore selectivity triggers for a series of nonsteroidal MR antagonists to improve selectivity over other members of the oxosteroid receptor family. A biaryl sulfonamide compound was identified in a high-throughput screening (HTS) campaign. The compound bound to MR with pKi=6.6, but displayed poor selectivity over the glucocorticoid receptor (GR) and the progesterone receptor (PR). Following X-ray crystallog. of MR in complex with the HTS hit, a compound library was designed that explored an induced-fit hypothesis that required movement of the Met852 side chain. An improvement in MR selectivity of 11- to 79-fold over PR and 23- to 234-fold over GR was obtained. Given the U-shaped binding conformation, macrocyclizations were explored, yielding a macrocycle that bound to MR with pKi=7.3. Two protein-ligand X-ray structures were determined, confirming the hypothesized binding mode for the designed compounds
Reference of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts