In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 141699-55-0, formula is C8H15NO3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Recommanded Product: tert-Butyl 3-hydroxyazetidine-1-carboxylate
McDermott, Lee A.;Iyer, Prema;Vernetti, Larry;Rimer, Shawn;Sun, Jingran;Boby, Melissa;Yang, Tianyi;Fioravanti, Michael;O’Neill, Jason;Wang, Liwei;Drakes, Dylan;Katt, William;Huang, Qingqiu;Cerione, Richard research published 《 Design and evaluation of novel glutaminase inhibitors》, the research content is summarized as follows. A novel set of GAC (kidney glutaminase isoform C) inhibitors able to inhibit the enzymic activity of GAC and the growth of the triple neg. MDA-MB-231 breast cancer cells with low nanomolar potency is described. Compounds in this series have a reduced number of rotatable bonds, improved C log Ps, microsomal stability and ligand efficiency when compared to the leading GAC inhibitors BPTES and CB-839. Property improvements were achieved by the replacement of the flexible n-diethylthio or the Bu moiety present in the leading inhibitors by heteroatom substituted heterocycloalkanes.
Recommanded Product: tert-Butyl 3-hydroxyazetidine-1-carboxylate, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts