On November 30, 2012, Sinha, Debarshi; Mandal, Tanmay; Gogoi, Sanjib; Goldman, Joshua J.; Zhao, John Cong-gui published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Asymmetric Aldol Reaction Catalyzed by Modularly Designed Organocatalysts. And the article contained the following:
The self-assembly of pre-catalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to a direct formation of the desired organocatalysts without any synthesis. These modularly designed organocatalysts (MDOs) may be used for catalyzed asym. aldol reaction. Depending on structure of the aldehyde substrates, the corresponding aldol products may be obtained in mediocre to excellent enantiomeric excess (ee) values (up to 92% ee) with moderate diastereoselectivities (up to 79:21 diastereomeric ratio, dr). The synthesis of the target compounds was achieved by a combination of amino acids and analogs, such as (αS)-α-amino-2-chlorobenzeneacetic acid, L-alanine, L-leucine, L-isoleucine. 3-methyl-L-valine, β-alanine. Cinchona alkaloids included N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, (8α,9R)-cinchonan-6′,9-diol (cupreine), (9S)-cinchonan-6′,9-diol (cupreidine), O-benzoylquinine, (8α,9R)-6′-methoxy-9-(phenylmethoxy)cinchonan (O-benzylquinine), etc. The title compounds thus formed included (4S)-4-hydroxy-4-(4-nitrophenyl)-2-butanone (4R)-4-hydroxy-4-(4-nitrophenyl)-2-butanone and (2R)-2-[(R)-hydroxy(4-nitrophenyl)methyl]cyclohexanone (I) and related substances, such as (3R)-tetrahydro-3-[(R)-hydroxy(4-nitrophenyl)methyl]-4H-pyran-4-one, (3R)-tetrahydro-3-[(R)-hydroxy(4-nitrophenyl)methyl]-4H-thiopyran-4-one. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH
The Article related to cinchona alkaloid amino acid chiral catalyst aldol reaction, cyclohexanone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst, pyranone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst, thiopyranone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst and other aspects.Recommanded Product: H-Phg(4-OH)-OH
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