Electric Literature of 33036-62-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation 9 1-Tetrahydropyranyloxy-4-bromobutane (Formula XXIII: A is trimethylene) Concentrated hydrobromic acid (75 drops of 48%) is added with stirring to a mixture of 4-bromobutanol (150 ml.) and dihydropyran (300 ml.) at 0. This mixture is stirred and allowed to warm slowly to 25 C. during 15 hours. Evaporation under reduced pressure gives a residue which is divided into two equal parts, each part being chromatographed on 1.5 kg. of silica gel, each column being eluted with 7.5 l. of 5% ethyl acetate in Skellysolve, B, and then with 4 l. of 7.5% ethyl acetate in Skellysolve B, collecting 500 ml. frations. Fractions 5- 11 from each column are evaporated to give a total of 240 g. of 1-tetrahydropyranyloxy-4-bromobutane.
According to the analysis of related databases, 33036-62-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; The Upjohn Company; US3959346; (1976); A;,
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