Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Computed Properties of 7748-36-9
Klug, Dana M.;Tschiegg, Laura;Diaz, Rosario;Rojas-Barros, Domingo;Perez-Moreno, Guiomar;Ceballos, Gloria;Garcia-Hernandez, Raquel;Martinez-Martinez, Maria Santos;Manzano, Pilar;Ruiz, Luis Miguel;Caffrey, Conor R.;Gamarro, Francisco;Pacanowska, Dolores Gonzalez;Ferrins, Lori;Navarro, Miguel;Pollastri, Michael P. research published 《 Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics》, the research content is summarized as follows. Human African trypanosomiasis (HAT) is a neglected tropical disease caused by infection with either of two subspecies of the parasite Trypanosoma brucei. Due to a lack of economic incentive to develop new drugs, current treatments have severe limitations in terms of safety, efficacy, and ease of administration.In an effort to develop new HAT therapeutics, author report the structure-activity relationships around T. brucei for a series of benzoxazepinoindazoles previously identified through a high-throughput screen of human kinase inhibitors, and the subsequent in vivo experiments for HAT. Author identified compound I (R1 = H; R2 = Me; R3 = NH2) , which showed an improved kinase selectivity profile and acceptable pharmacokinetic parameters, as a promising lead. Although treatment with I (R1 = H; R2 = Me; R3 = NH2) cured 60% of mice in a systemic model of HAT, the compound was unable to clear parasitemia in a CNS model of the disease. Author also report the results of cross-screening these compounds against T. cruzi, L. donovani, and S. mansoni.
7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Computed Properties of 7748-36-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts