In 2022,Xie, Qi; Zhang, Xiuqi; Liu, Huijin; Zhang, Fukuan; Luo, Xuzhong; Luo, Haiqing published an article in Asian Journal of Organic Chemistry. The title of the article was 《Copper-Catalyzed N-Arylation of Indoles and Anilines with Aryltrialkoxysilanes》.Name: Oxetan-3-ol The author mentioned the following in the article:
An efficient copper-catalyzed aerobic Chan-Lam type N-arylation of various indoles and anilines with structurally diverse aryltrialkoxysilanes to afford phenyl-indoles I [R = H, 7-Me, 5-F, etc.; R1 = H, 4-Me, 4-tBu, etc.] and diphenylamines II [R2 = 4-Me, 4-Cl, 4-F, etc.] under mild conditions was reported. This silicon-based protocol enabled the efficient C-N cross-coupling of indoles and anilines with user-friendly organosilicon reagents by employing inexpensive and nontoxic Cu(OAc)2, which was efficient and practical without the addition of other ligands, bases and metal oxidants. This transformation was compatible with a wide range of substrates, and typically proceeded with high efficiency as well as with good functional group compatibility. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol
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