Formula: C3H6O2In 2022 ,《Visible-Light-Induced [2+2+1] Dearomative Cascade Cyclization of Indole/Furan Alkynes to Synthesize Sulfonyl Polycycles》 was published in Advanced Synthesis & Catalysis. The article was written by Luo, Jiajun; Zeng, Guohui; Cao, Xiaohui; Yin, Biaolin. The article contains the following contents:
Herein, authors report a visible-light-induced [2+2+1] dearomative cascade cyclization of indole/furan alkynes with NaHSO3, providing an array of diverse highly strained sulfonyl polycycles. Compared to authors previous work, this method does not require the use of addnl. sacrificial oxidants and have wider reaction scope. Preliminary mechanistic studies suggest that the indole moiety initiated the reaction, which proceeded via single-electron oxidation pathway. An alkenyl radical formed by intramol. addition capture SO2, and the resulting species is cyclized to furnish the final product. Also, DFT calculations disclosed that the groups on the indole ring or at the side chain probably affect the single electron distribution at the reaction site of IM-RC-I, and the distribution may be a decisive factor of spirocyclization. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2
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