Electric Literature of C7H9NO2In 2020 ,《A Molecular Capsule with Revolving Doors Partitioning Its Inner Space》 appeared in Chemistry – A European Journal. The author of the article were Lei, Zhiquan; Finnegan, Tyler J.; Gunawardana, Vageesha W. Liyana; Pavlovic, Radoslav Z.; Xie, Han; Moore, Curtis E.; Badjic, Jovica D.. The article conveys some information:
Covalent capsule 1 was designed to include two mol. baskets linked with three mobile pyridines tucked into its inner space. On the basis of both theory (DFT) and experiments (NMR and X-ray crystallog.), we found that the pyridine “”doors”” split the chamber (380 Å3) of 1 so that two equally sizeable compartments (190 Å3) became joined through a conformationally flexible aromatic barrier. The compartments of such unique host could be populated with CCl4 (88 Å3; PC=46%), CBr4 (106 Å3; 56%) or their combination CCl4/CBr4 (PC=51%), with thermodn. stabilities ΔG° tracking the values of packing coefficients (PC). Halogen (C-X···π) and hydrogen bonding (C-H···X) contacts held the haloalkane guests in the cavities of 1. The consecutive complexations were found to occur in a neg. allosteric manner, which we propose to result from the induced-fit mode of complexation. Newly designed 1 opens a way for probing the effects of inner conformational dynamics on noncovalent interactions, reactivity and intramol. translation in confined spaces of hollow mols. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Electric Literature of C7H9NO2)
2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Electric Literature of C7H9NO2
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