《Trifluoromethylselenolation and N-acylation of indoles with [Me4N][SeCF3]》 was written by Tan, Kai-Li; Wang, Hao-Nan; Dong, Tao; Zhang, Cheng-Pan. Name: Oxetan-3-ol And the article was included in Organic & Biomolecular Chemistry in 2021. The article conveys some information:
An efficient method for oxidative trifluoromethylselenolation/N-acylation of indoles with excess [Me4N][SeCF3] in the presence of acyl peroxides and their derivatives is described. The reaction is easy to handle, proceeds smoothly at room temperature under metal-free conditions, and shows advantages such as good functional group tolerance, excellent regioselectivity, and compatibility of a number of substrates, producing 1-acyl and 3-trifluoromethylselanyl substituted indoles I (R1 = H, 5-CN, 4-Cl, etc.; R2 = H, Me; Ar = Ph, 3-ClC6H4, 4-FC6H4, etc.) in good yields. Acyl peroxides and peroxycarboxylic acid behave as both oxidants and acyl sources in the transformation. This one-pot procedure provides a convenient access to a new class of indole derivatives, representing the first trifluoromethylselanyl bifunctionalization of indoles with the nucleophilic [Me4N][SeCF3] reagent. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol
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