In 2022,Laha, Joydev K.; Gupta, Pankaj published an article in Journal of Organic Chemistry. The title of the article was 《Sulfoxylate Anion Radical-Induced Aryl Radical Generation and Intramolecular Arylation for the Synthesis of Biarylsultams》.Formula: C3H6O2 The author mentioned the following in the article:
A green and practically useful synthetic protocol to access diverse six- and seven-membered biarylsultams I (R = H, Me, Ph; R1 = H, OMe, OPh, Me; R2 = H; R1R2 = -CH=CH-CH=CH-; R3 = H, Me, Cl, OCF3, etc.; R4 = H, Me), and e.g., II, especially with a free NH group including demonstration of a gram-scale synthesis was reported. The sulfoxylate anion radical (SO2-•), generated in situ from the reagents rongalite or sodium dithionite (Na2S2O4), was found to be the key single electron transfer agent forming aryl radicals from aryl halides, e.g., 2-bromo-N-phenylbenzene-1-sulfonamide which upon intramol. arylation gives biarylsultams I, and e.g., II, with good to excellent yields. The approach features generation of aryl radicals that remained under-explored, use of a cheap and readily available industrial reagents, and transition metal-free, mild, and green reaction conditions. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2
Referemce:
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Alcohols – Chemistry LibreTexts