Panczyk-Straszak, Katarzyna’s team published research in ChemistrySelect in 2022 | CAS: 27489-62-9

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C6H13NO

In 2022,Panczyk-Straszak, Katarzyna; Rapacz, Anna; Marona, Henryk; Zelaszczyk, Dorota; Karczewska, Elzbieta; Zajac, Martyna; Skiba-Kurek, Iwona; Siwek, Agata; Waszkielewicz, Anna published an article in ChemistrySelect. The title of the article was 《Design, Synthesis and Anticonvulsant Activity of New Phenoxyalkyl, Phenoxyethoxyethyl and Phenoxyacetyl Derivatives of Aminoalkanols》.Electric Literature of C6H13NO The author mentioned the following in the article:

Forty new aminoalkanol derivatives with potential anticonvulsant activity were designed and synthesized. In vivo studies (mice, i.p. administration) showed anticonvulsant activity (maximal electroshock seizure test, MES test) of nineteen compounds, (ED50 values and protective indexes PI ranging 22.62-78.30 mg/kg b.w. and 1.78-4.25, resp.). Compounds 30 (R,S-1-((2-(2-(2-chloro-5-methylphenoxy)ethoxy)ethyl)amino)propan-2-ol), 31 (R,S-2-((2-(2-(2-chloro-5-methylphenoxy)ethoxy)ethyl)amino)propan-1-ol) and 33 (S enantiomer of 31) showed relatively low ED50 values (26.45-34.26 mg/kg b.w.) accompanied by PI indexes above 3. Compounds 30 and 31 were investigated in terms of mechanism of action (5-HT1A receptors binding assay and in silico database screening) and safety against gastrointestinal flora (both compounds proved safe). An integral part of the study was also a comprehensive structure-activity relationship, including current and previously obtained results for aminoalkanol derivatives In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts