Quality Control of Oxetan-3-olIn 2020 ,《Pd-Catalyzed ortho-C-H Olefination of Benzenesulfonamides Directed by 7-Azaindole》 appeared in Asian Journal of Organic Chemistry. The author of the article were Huo, Xing; Han, Jun; Yan, Xiaoxiao; Zhang, Heng; Xiong, Juan; Liu, Jian; Wang, Xiaolei; Li, Huilin; Huo, Leiming. The article conveys some information:
Demonstrated herein is a Pd-catalyzed ortho-C-H olefination of benzenesulfonamides I [R = H, Me, Cl; R1 = H; R2 = H, Cl, t-Bu, Ph, etc; R3 = H, Me, Cl; R3 = H, Me, Cl; R4 = H, Me, Cl; R1R2 = -(CH2)2O-; R2R3 = -(CH=CHCH=CH)-] using 7-azaindole as the directing group. This reaction proceeds with exclusive ortho selectivity, high efficiency and broad substrate scope. This method also provides access to sulfonic acids and ortho-alkylated sulfonamides I [R = Me; R1 = R2 = R3 = H; R4 = CH=CHC(O)OH, (CH2)2C(O)OCH2CH3]. Control experiments provides some insightful evidences to the mechanism and the plausible catalytic cycle is proposed to go through a unique seven-membered palladacycle species. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Quality Control of Oxetan-3-ol) was used in this study.
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Quality Control of Oxetan-3-ol
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