Related Products of 534-03-2In 2021 ,《Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction》 was published in Journal of Medicinal Chemistry. The article was written by Muszak, Damian; Surmiak, Ewa; Plewka, Jacek; Magiera-Mularz, Katarzyna; Kocik-Krol, Justyna; Musielak, Bogdan; Sala, Dominik; Kitel, Radoslaw; Stec, Malgorzata; Weglarczyk, Kazimierz; Siedlar, Maciej; Domling, Alexander; Skalniak, Lukasz; Holak, Tad A.. The article contains the following contents:
We describe a new class of potent PD-L1/PD-1 inhibitors based on a terphenyl scaffold that is derived from the rigidified biphenyl-inspired structure. Using in silico docking, we designed and then exptl. demonstrated the effectiveness of the terphenyl-based scaffolds in inhibiting PD-1/PD-L1 complex formation using various biophys. and biochem. techniques. We also present a high-resolution structure of the complex of PD-L1 with one of our most potent inhibitors to identify key PD-L1/inhibitor interactions at the mol. level. In addition, we show the efficacy of our most potent inhibitors in activating the antitumor response using primary human immune cells from healthy donors. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 534-03-2
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