COA of Formula: C3H5F3OOn March 10, 2022, Empel, Claire; Pei, Chao; He, Feifei; Jana, Sripati; Koenigs, Rene M. published an article in Chemistry – A European Journal. The article was 《Proton or Carbene Transfer? On the Dark and Light Reaction of Diazoalkanes with Alcohols》. The article mentions the following:
A fundamental understanding of the reaction of diazoalkanes with alcs. to made this transformation amenable to a generalized approach towards formal alkylation reactions of alcs. with diazoalkanes was aimed. Exptl. and theor. studies suggested a direct proton transfer only in exceptional cases. In a more general setting, such O-H functionalization proceeded both under dark and photochem. conditions via a key hydrogen-bonded singlet carbene intermediate that underwent a protonation-addition mechanism. Applications of this approach in O-H functionalization reactions of alcs., including simple fluorinated, halogenated and aliphatic alcs. and showcase functional-group tolerance of this method in the reaction of biol. active and pharmaceutically relevant alcs. was concluded. In addition to this study using 3,3,3-Trifluoropropan-1-ol, there are many other studies that have used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2COA of Formula: C3H5F3O) was used in this study.
3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.COA of Formula: C3H5F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts