《Synthesis and Antitumor Activity of 2-[3-(2-Chloroethyl)-3-Nitrosoureido]-1,3-Propanediol (Chlonisol)》 was published in Pharmaceutical Chemistry Journal in 2020. These research results belong to Stukov, A. N.; Esikov, K. A.; Usmanova, L. M.; Kharitonova, N. N.; Vershinina, S. F.; Zmitrichenko, Yu. G.; Filatova, L. V.; Latipova, D. Kh.; Semenov, A. L.; Bespalov, V. G.; Semiglazova, T. Yu.. SDS of cas: 534-03-2 The article mentions the following:
The reaction of 2-chloroethylisocyanate and 2-amino-1,3-propanediol in MeCN-MeOH yielded 2-[3-(2-chloroethyl) ureido]-1,3-propanediol, which was nitrosated using sodium nitrite in 50% formic acid to obtain 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol). A single administration of chlonisol at a non-toxic dose of 15 mg/kg increased by 170% the median life expectancy of mice with P-388 leukemia and cured 100% of rats with Walker 256 carcinosarcoma. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.SDS of cas: 534-03-2
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