《Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins》 was written by Preston, Alex; Atkinson, Stephen; Bamborough, Paul; Chung, Chun-wa; Craggs, Peter D.; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Jones, Emma J.; Lindon, Matthew; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Seal, Jonathan; Taylor, Simon; Wall, Ian; Watson, Robert J.; Woolven, James; Demont, Emmanuel H.. Related Products of 27489-62-9 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:
Pan-bromodomain and extra terminal domain (BET) inhibitors interact equipotently with the eight bromodomains of the BET family of proteins and have shown profound efficacy in a number of in vitro phenotypic assays and in vivo pre-clin. models in inflammation or oncol. A number of these inhibitors have progressed to the clinic where pharmacol.-driven adverse events have been reported. To better understand the contribution of each domain to their efficacy and improve their safety profile, selective inhibitors are required. This article discloses the profile of GSK046, also known as iBET-BD2(I), a highly selective inhibitor of the second bromodomains of the BET proteins that has undergone extensive pre-clin. in vitro and in vivo characterization. In addition to this study using trans-4-Aminocyclohexanol, there are many other studies that have used trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9) was used in this study.
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Related Products of 27489-62-9
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