Yayli, Nurettin; Kilic, Gozde; Celik, Gonca; Kahriman, Nuran; Kanbolat, Seyda; Bozdeveci, Arif; Karaoglu, Sengul Alpay; Aliyazicioglu, Rezzan; Sellitepe, Hasan Erdinc; Dogan, Inci Selin; Aydin, Ali published an article in 2021. The article was titled 《Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities》, and you may find the article in Turkish Journal of Chemistry.Product Details of 26153-38-8 The information in the text is summarized as follows:
In this study, hydroxy benzoin R1C(O)CH(OH)R2 (I) (R1 = 3-hydroxyphenyl, 4-hydroxyphenyl, 3,5-dihydroxyphenyl; R2 = Ph, 3-hydroxyphenyl, 3,5-dihydroxyphenyl; R1 = R2 = 3,5-dihydroxyphenyl), benzil R1C(O)C(O)R2, and benzoin/benzil-O-β;-D-glucosides R3C(O)CH(OH)R4 [R3 = (3-D-glucopyranosyl)phenyl, (4-D-glucopyranosyl)phenyl, (3,5-di-D-glucopyranosyl)phenyl, 3-hydroxyphenyl; R4 = Ph, 3-hydroxyphenyl, (3-D-glucopyranosyl)phenyl]/R3C(O)C(O)R5 (R5 = Ph, 3-hydroxyphenyl, 4-hydroxyphenyl) were synthesized to investigate their biol. activities. An efficient method for synthesizing hydroxy benzoin compounds (I) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 G (-), 4/6 G (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds were evaluated. And also, four most active compounds (R1C(O)CH(OH)R2 (R1 = R2 = 3-hydroxyphenyl) (II), R1C(O)C(O)R2 (R1 = 3-hydroxyphenyl; R2 = 4-hydroxyphenyl), R3C(O)CH(OH)R4 [R3 = R4 = (3-D-glucopyranosyl)phenyl, 3-hydroxyphenyl], and R3C(O)C(O)R5 (R3 = (3-D-glucopyranosyl)phenyl; R5 = 4-hydroxyphenyl)) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound (II) showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program’s help. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Product Details of 26153-38-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts