In 2022,Hwang, Jimin; Qiu, Xiaqiu; Borgelt, Lydia; Haacke, Neele; Kanis, Laurin; Petroulia, Stavroula; Gasper, Raphael; Schiller, Damian; Lampe, Philipp; Sievers, Sonja; Imig, Jochen; Wu, Peng published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents》.Application In Synthesis of Oxetan-3-ol The author mentioned the following in the article:
Aminothiophene is a scaffold that is widely present in drugs and biol. active small mols. as chem. probes. In this study, 43 compounds sharing a 2-aminothiophenone-3-carboxylate (ATPC) scaffold, known to activate the RNase L (RNase L), were synthesized and selected ATPCs showed enhancement of thermal stability of RNase L upon binding. Screening of antiproliferation activities against human cancer cell lines revealed that ATPCs represented by compounds 4l and 50 showed potent single-digit micromolar antiproliferation activity against human cancer cell lines. Compounds 4l and 50 exhibited time- and dose-dependent proliferation inhibition, induced cellular apoptosis measured by cleaved PARP and via flow cytometry, inhibited cell migration, and inhibited cell colony formation. Combining the results reported in this work, ATPCs were evaluated as potential anticancer agents mediated by RNase L-binding and apoptosis induction. The work contributes to the study on the polypharmacol. properties of aminothiophene-containing small mols. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol
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