Name: 3,5-DihydroxybenzaldehydeIn 2019 ,《A novel resveratrol derivative induces oxidative stress, G1 cell cycle arrest and premature senescence in A549 cells》 appeared in Latin American Journal of Pharmacy. The author of the article were Yang, Jie; Li, Jing; Qu, Xiao-Yu; Liu, Guo-Yun; Liu, Ren-Min. The article conveys some information:
Resveratrol has been reported to be a potential chemopreventive and anticancer agent. However, its poor bioavailability is being considered as a major obstacle in translating its effects in humans. Here, we report the synthesis and the anti-proliferative activities of fluorinated groups (CF3 and OCF3) substituted resveratrol derivatives A novel OCF3 substituted active derivative (A-3) owning the excellent stability and cell uptake ability in A549 cells, could improve the anti-proliferative activity (about 5 fold). In addition, A-3 could cause a clear block of cells in G1 phase (81.5%) and induce obvious premature senescence, via an apoptosis-independent mechanism; while resveratrol could cause an accumulation of cells in S phase (57.8%). Besides, A-3 treatment could cause an oxidized cellular environment in A549 cells. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Name: 3,5-Dihydroxybenzaldehyde
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts