The author of 《Post-synthetic transamination at position N4 of cytosine in oligonucleotides assembled with routinely used phosphoramidites》 were Lartia, Remy; Vallee, Coelio; Defrancq, Eric. And the article was published in Organic & Biomolecular Chemistry in 2020. HPLC of Formula: 6346-09-4 The author mentioned the following in the article:
The com. available and cheap nucleotide phosphoramidites are routinely used for the oligonucleotide (ODN) assembly. T, isobutyryl-dG (iBudG), benzoyl-dA (BzdA), acetyl-dC (AcdC) and benzoyl-dC (BzdC) derivatives are sufficient to produce orthogonally protected ODNs. Clean and efficient (ca. 30%-70% yield) post-synthetic amination of an ODN assembled with such phosphoramidites was selectively achieved at the N4 position of a singly introduced BzdC. Such a method represents a novel and cheap strategy for the user-friendly post-modification of oligonucleotides at the internal position. After reading the article, we found that the author used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4HPLC of Formula: 6346-09-4)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.HPLC of Formula: 6346-09-4
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