Zhang, Zhuming; Ghosh, Avijit; Connolly, Peter J.; King, Peter; Wilde, Thomas; Wang, Jianyao; Dong, Yawei; Li, Xueliang; Liao, Daohong; Chen, Hao; Tian, Gaochao; Suarez, Javier; Bonnette, William G.; Pande, Vineet; Diloreto, Karen A.; Shi, Yifan; Patel, Shefali; Pietrak, Beth; Szewczuk, Lawrence; Sensenhauser, Carlo; Dallas, Shannon; Edwards, James P.; Bachman, Kurtis E.; Evans, David C. published their research in Journal of Medicinal Chemistry on August 12 ,2021. The article was titled 《Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer》.Computed Properties of C3H5F3O The article contains the following contents:
Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of cardiovascular events. Here, we report a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure. By establishing acute ex vivo 18F-FDG uptake attenuation as an efficacy proxy, we identified a subset of analogs that demonstrated statistically significant in vivo dose-dependent inhibition of adenoma progression and survival extension in an APCmin/+ mouse model. However, in vitro-in vivo correlation anal. showed their chemoprotective effects were driven by residual systemic COX-2 inhibition, rationalizing their less than expected efficacies and highlighting the challenges associated with COX-2-mediated CRC disease chemoprevention. In addition to this study using 3,3,3-Trifluoropropan-1-ol, there are many other studies that have used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Computed Properties of C3H5F3O) was used in this study.
3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Computed Properties of C3H5F3O
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