《Thiourea-Catalyzed C-F Bond Activation: Amination of Benzylic Fluorides》 was published in Chemistry – A European Journal in 2020. These research results belong to Houle, Camille; Savoie, Paul R.; Davies, Clotilde; Jardel, Damien; Champagne, Pier Alexandre; Bibal, Brigitte; Paquin, Jean-Francois. Related Products of 13325-10-5 The article mentions the following:
The first thiourea-catalyzed C-F bond activation was described. The use of a thiourea catalyst and Ti(OiPr)4 as a fluoride scavenger allowed the amination of benzylic fluorides to benzylic amines RC6H4CH2R1 [R = 2-Me, 3-Cl, 4-Ph, etc.; R1 = NHPh, morpholino, imidazol-1-yl, etc.] in moderate to excellent yields. Preliminary results with S- and O-based nucleophiles were also presented. DFT calculations revealed the importance of hydrogen bonds between the catalyst and the fluorine atom of the substrate to lower the activation energy during the transition state. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5
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