《A new fluorescent probe for sensing of biothiols and screening of acetylcholinesterase inhibitors》 was written by Wu, Shengjun; Li, Yuge; Deng, Tao; Wang, Xiaojuan; Hu, Shiyou; Peng, Guiyuan; Huang, Xin-an; Ling, Yanwu; Liu, Fang. SDS of cas: 89466-08-0 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:
A new N2O-type BODIPY probe (LF-Bop)(I) has been proposed for the selective and sensitive detection of biol. relevant small mol. thiols. This detection is based on the Michael addition reaction between the thiol and nitrostyrene groups in the probe, which decreases the quenching effect from the nitro group, thus resulting in the recovery of the deep-red fluorescence from the BODIPY structure. LF-Bop is able to detect all tested free thiols through a fluorescence turn-on assay. The lowest limit of detection (LOD) for glutathione is down to nanomolar levels (220 nM). Based on this probe, the authors have developed a new fluorescence assay for the screening of acetylcholinesterase inhibitors. In total, 11 natural and synthetic alkaloids have been evaluated. Both exptl. measurements and theor. mol. docking results reveal that both natural berberine and its synthetic derivative dihydroberberine are potential inhibitors of acetylcholinesterase. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0) was used in this study.
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. SDS of cas: 89466-08-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts