《Solvolytic Reactivity of Heptafluorobutyrates and Trifluoroacetates》 was written by Denegri, Bernard; Kronja, Olga. Name: (3-Chlorophenyl)(phenyl)methanol And the article was included in Journal of Organic Chemistry on August 21 ,2009. The article conveys some information:
X,Y-substituted benzhydryl heptafluorobutyrates and trifluoroacetates were subjected to solvolysis in various methanol/water, ethanol/water, and acetone/water mixtures at 25 °C. The LFER equation log k = sf(Ef + Nf) was used to derive the nucleofuge-specific parameters (Nf and sf) for SN1-type reaction. In comparison with TFA, the HFB leaving group is a better nucleofuge for <0.5 unit of Nf. X,Y-Substituted benzhydryl trifluoroacetates solvolyze by way of SN1 reactions unless electron-withdrawing groups are attached to aromatic rings. In such cases the substrates solvolyze faster than predicted for the SN1 route because of the change in mechanism. X,Y-Substituted benzhydryl heptafluorobutyrates examined here (Ef ≥ -7.7) solvolyze according to the SN1 pathway. The almost parallel log k vs. Ef lines in various solvents for HFBs and TFAs, and the corresponding slope parameters (sf are in the range of 0.91 and 0.83), indicate early TS with moderately advanced charge separation NBO charges of HFB and TFA anions and the affinities obtained, all calculated at the PCM-B3LYP/6-311+G(2d,p)//PCM-B3LYP/6-311+G(2d,p) level, revealed that the HFB anion slightly better delocalizes the developing neg. charge than TFA, and that the affinity of the benzhydrylium ion is slightly larger toward TFA than toward the HFB anion, which is in accordance with the greater solvolytic reactivity of HFB.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Name: (3-Chlorophenyl)(phenyl)methanol) was used in this study.
(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Name: (3-Chlorophenyl)(phenyl)methanol
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