《Towards Photochromic Azobenzene-Based Inhibitors for Tryptophan Synthase》 was written by Simeth, Nadja A.; Kinateder, Thomas; Rajendran, Chitra; Nazet, Julian; Merkl, Rainer; Sterner, Reinhard; Koenig, Burkhard; Kneuttinger, Andrea C.. HPLC of Formula: 156-87-6This research focused ontryptophan synthase inhibitor antibiotics photoresponsive; antibiotics; azo compounds; enzymes; inhibitors; photopharmacology. The article conveys some information:
Light regulation of drug mols. has gained growing interest in biochem. and pharmacol. research in recent years. In addition, a serious need for novel mol. targets of antibiotics has emerged presently. Herein, the development of a photocontrollable, azobenzene-based antibiotic precursor towards tryptophan synthase (TS), an essential metabolic multienzyme complex in bacteria, is presented. The compound exhibited moderately strong inhibition of TS in its E configuration and five times lower inhibition strength in its Z configuration. A combination of biochem., crystallog., and computational analyses was used to characterize the inhibition mode of this compound Remarkably, binding of the inhibitor to a hitherto-unconsidered cavity results in an unproductive conformation of TS leading to noncompetitive inhibition of tryptophan production In conclusion, we created a promising lead compound for combating bacterial diseases, which targets an essential metabolic enzyme, and whose inhibition strength can be controlled with light. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6) was used in this study.
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.HPLC of Formula: 156-87-6
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