Zalesak, Frantisek; Kovac, Ondrej; Lachetova, Eliska; Stastna, Nikola; Pospisil, Jiri published their research in Journal of Organic Chemistry in 2021. The article was titled 《Unified Approach to Benzo[d]thiazol-2-yl-Sulfonamides》.Application of 4048-33-3 The article contains the following contents:
In this paper, a unified approach to N-substituted and N,N-disubstituted benzothiazole (BT) sulfonamides I [R = n-Bu, cyclohexyl, Bn, furan-2-ylmethyl, etc.; R1 = H, Me; RR1 = -(CH2)5-, -(CH2)2CH(OH)(CH2)2], II, III (R2 = propan-2-yl, Bn, oxiran-2-ylmethyl, etc.; RR2 = -(CH2)6-) and IV (Ar = Ph, 3-fluorophenyl, 4-chlorophenyl, etc.) was reported. The approach to BT-sulfonamides I and II starts from simple com. available building blocks (benzo[d]thiazole-2-thiol and primary and secondary amines such as allylamine, benzylamine, piperidine, etc.) that are connected via (a) a S oxidation/S-N coupling approach, (b) a S-N coupling/S-oxidation sequence, or via (c) a S-oxidation/S-F bond formation/SuFEx approach. The labile N-H bond in N-monoalkylated BT-sulfonamides III (pKa (BTSO2N(H)Bn) = 3.34 ± 0.05) further allowed to develop a simple weak base-promoted N-alkylation method and a stereoselective microwave-promoted Fukuyama-Mitsunobu reaction. N-Alkyl-N-aryl BT-sulfonamides IV were accessed with the help of the Chan-Lam coupling reaction. Developed methods were further used in stereo and chemoselective transformations of podophyllotoxin and several amino alcs. such as 3-aminopropan-1-ol and 6-aminohexan-1-ol. In the experiment, the researchers used many compounds, for example, 6-Aminohexan-1-ol(cas: 4048-33-3Application of 4048-33-3)
6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Application of 4048-33-3
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