Reference of 29683-23-6, Adding some certain compound to certain chemical reactions, such as: 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol,molecular formula is C5H10OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29683-23-6.
Methi 7-cyciopropyl-6-hydroxypyrazoio[1 ,5-a]pyridine-3-carboxyiate (0. 100 g. 0.431 rnrnoi), tetrahydro-2H-thiopyram4oi (0.102 g, 0.861 mmoi), and 1,1 (azodicarbonvl)dipiperi dine (0.326 g. 1.29 rnmol) were placed in a pressure vial. Then, anhydrous Ph]?ie (4 rnL) and tri-N-butyiphosphine (0.323 rnL, 1.29 rnmoi) were added,and the reaction mixture was stirred at 140 C under microwave irradiation for 15 mm. The reaction mixture was quenched with MeOl-I (5 mL), diluted with MeOH/DCM (20 mE), and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (0-50% EIOAc/DCM gradient) to give methyl 7-cyciopropyl-6- ((tetrahydro-2H-thiopyran-4-yl)oxy)pyrazoio[ I ,5-ajpyridine-3-carboxylate (0.134 g, 94% yield) as a colorless syrup. MS (ESI) ,n??: 333.1 (M-HH). ?H-NMR: (500 MHz,CDCI3) oe ppm 8.38 (s, 11-1), 7.99 (d, J:::94 Hz, 1K), 7.22 (d. J=9.6 Hz, iii), 4.31 4.22(m, 11:1), 3.90 (s, 31:1), 2.97 – 2.88 (in. 2H). 265 2.55 (m, 21:1), 2.44 – 2.36 (in. 1K). 230220 (m, 2H), 2.08 – 1.98 (m, 2H), 1.46 – 139 (m, 2H), 1.21 – 1.15 (m, 2H),
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29683-23-6, Tetrahydro-2H-thiopyran-4-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SMITH II, Leon M.; LADZIATA, Vladimir; DELUCCA, Indawati; PINTO, Donald, J., P.; ORWAT, Michael J.; DILGER, Andrew K.; PABBISETTY, Kumar Balashanmuga; YANG, Wu; SHAW, Scott A.; GLUNZ, Peter W.; PANDA, Manoranjan; (612 pag.)WO2017/123860; (2017); A1;,
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