In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, the common compound, a new synthetic route is introduced below. Formula: C3H6F3NO
A solution of 150 mg intermediate 17, 1 12 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 248 mg HATU and 0.23 mL ethyldiisopropylamine in 7.5 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was quenched by water, and the mixture was extracted with dichloromethane two times. The combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.1 Vol% formic acid)-gradient)) to yield 130 mg 6-(4-chlorophenyl)-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypropyl)-2,3- dihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-de): delta = 3.47 (ddd, 1 H); 3.75 (ddd, 1 H); 4.17-4.27 (m, 1 H); 6.66 (d, 1 H); 7.39 (ddt, 1 H); 7.53-7.66 (m, 5H); 8.00 (d, 2H); 8.67 (s, 1 H); 9.64 (t, 1 H).
The synthetic route of 431-38-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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