Wang, Huamin; Bellotti, Peter; Zhang, Xiaolong; Paulisch, Tiffany O.; Glorius, Frank published the artcile< A base-controlled switch of SO2 reincorporation in photocatalyzed radical difunctionalization of alkenes>, Application of C4H8O, the main research area is trifluoromethylated sulfonyl ketone preparation chemoselective photochem; alkene radical difunctionalization photocatalyst.
Control of selectivity is a pivotal challenge in radical chem. owing to the high reactivity and instability of radical species. Herein, a switchable, base-controlled strategy toward the reincorporation/release of SO2 in photocatalyzed radical difunctionalization of alkenes has been described. By this chemodivergent strategy, a variety of valuable, otherwise difficult-to-access γ-trifluoromethylated ketones and trifluoromethylated sulfonyl ketones can be selectively furnished from the same starting materials. This method features high chemoselectivity, a broad substrate scope, excellent functional group tolerance, and facile scale-up and was applied in a one-pot synthetic procedure. Evaluation of the reaction conditions and mechanistic studies indicate that the choice of base can invert the chemoselectivity of the reaction, demonstrating control over a challenging radical selectivity pattern.
Chem published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts