Electric Literature of 6971-51-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6971-51-3, name is (3-Methoxyphenyl)methanol. A new synthetic method of this compound is introduced below.
General procedure: Geranyl bromide 12a was synthesized from geraniol via the reaction with PBr3.18 PBr3 (8.9 mmol) was added to cooled (0-5C) solution of geraniol (26.7 mmol) in dry ether (30 ml) and the reaction mixture was stirred for 2 h at r.t. Saturated aqueous NaHCO3 was added and the product was extracted with ether. The extracts were washed with brine, dried with Na2SO4 and evaporated. Other used bromides 12b-e were synthesized as described above. Compounds 12a, 12b, 12c and 12e (the yields 91%, 55%, 60% and 65%, respectively) were sufficiently pure and used for the next step without purification. The compound 12d was purified by column chromatography on SiO2, eluent – hexane (yield 24%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6971-51-3, (3-Methoxyphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Khomenko, Tatyana M.; Zarubaev, Vladimir V.; Orshanskaya, Iana R.; Kadyrova, Renata A.; Sannikova, Victoria A.; Korchagina, Dina V.; Volcho, Konstantin P.; Salakhutdinov, Nariman F.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 13; (2017); p. 2920 – 2925;,
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