Liang, Yun-Yan; Huang, Jing; Ouyang, Xuan-Hui; Qin, Jing-Hao; Song, Ren-Jie; Li, Jin-Heng published the artcile< Radical-mediated alkoxypolyhaloalkylation of styrenes with polyhaloalkanes and alcohols via C(sp3)-H bond cleavage>, Application In Synthesis of 627-27-0, the main research area is polyhaloalkane preparation; styrene polyhaloalkane alc alkoxypolyhaloalkylation.
A new radical-mediated alkoxypolyhaloalkylation of styrenes RCH=C(R1)R2 (R = H, Me; R1 = 4-methoxyphenyl, 3-methylthiophen-2-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc.; R2 = H, Me, Ph) with polychloroalkanes HCR3R4R5 (R3 = H, Cl, Br; R4 = H, Cl, Br; R5 = Cl, Br, bromomethyl, chloromethyl, dichloromethyl) and alcs. R6OH (R6 = Me, 2,2-dimethylpropyl, 4-phenylbutyl, adamantan-2-yl, etc.) and aniline is provided for the facile synthesis of complex polyhaloalkanes R1R2C(OR6)C(R)CR3R4R5 and N-(3,3,3-trichloro-1-(4-methoxyphenyl)propyl)aniline. The 4-methoxybenzenediazonium tetrafluoroborate is a good radical initiator for this transformation. This protocol is well applied to the late-stage functionalization of complex mols., including vitamin E, estrone and cholesterol derivs e.g., I.
Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts