Quivelli, Andrea F.; D’Addato, Giovanna; Vitale, Paola; Garcia-Alvarez, Joaquin; Perna, Filippo M.; Capriati, Vito published the artcile< Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water>, Computed Properties of 76-84-6, the main research area is tertiary alc preparation; organometallic compound ester nucleophilic addition.
An efficient protocol was developed for the synthesis of tertiary alcs. R1C(OH)(R2)R2 [R1 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.; R2 = Me, i-Pr, Ph, etc.] via nucleophilic addition of organometallic compounds of s-block elements (Grignard and organolithium reagents) to esters performed in the biodegradable choline chloride/urea eutectic mixture or in water. This approach displayed a broad substrate scope, with the addition reaction proceeded quickly (20 s reaction time) and cleanly, at ambient temperature and under air, straightforwardly furnished the expected tertiary alcs. in yields of up to 98%. The practicability of the method was exemplified by the sustainable synthesis of some representative S-trityl-L-cysteine derivatives, which were a potent class of Eg5 inhibitors, also via telescoped one-pot processes.
Tetrahedron published new progress about Deep eutectic solvents. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts