Liao, Yangzhen; Ran, Yu; Liu, Guijun; Liu, Peijun; Liu, Xiaozu published the artcile< Transition-metal-free radical relay cyclization of vinyl azides with 1,4-dihydropyridines involving a 1,5-hydrogen-atom transfer: access to α-tetralone scaffolds>, COA of Formula: C9H8O, the main research area is tetralone scaffold preparation green chem diastereoselective; vinyl azide dihydropyridine radical hydrogen transfer cyclization.
The remote C(sp3)-H functionalization enabled by a radical-mediated 1,5-hydrogen-atom transfer (HAT) process using 1,4-dihydropyridines I (R = cyclohexyl, 3-phenyl-2-methylpropyl, 1-cyclohexylethyl, etc.; R1 = C(O)OEt, CN) and vinyl azides R2C(=CH2)N3 (R2 = 2-chlorophenyl, 1-naphthyl, benzofuran-2-yl, etc.) as precursors has been described. In this study, 1,4-dihydropyridines I can function as 1,2-diradical synthons through sequential homolytic cleavage of an ipso-C-C bond and a β-C(sp3)-H bond. This reaction offers facile access to a diverse range of α-tetralones e.g., II with excellent stereoselectivity. The utility of the present method is further highlighted by its application to rapid assembly of the tetracyclic scaffold present in furanosteroids as well as the synthesis of aromatic amines.
Organic Chemistry Frontiers published new progress about Alkyl azides Role: RCT (Reactant), RGT (Reagent), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, COA of Formula: C9H8O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts