Application of 16545-68-9 ,Some common heterocyclic compound, 16545-68-9, molecular formula is C3H6O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1: 1-bromo-5-cyclopropyloxy-2-methyl-4-nitrobenzene 1-bromo-5-fluoro-2-methyl-4-nitrobenzene (70g , 0.3mol), freshly prepared cyclopropanol diethyl ether complex (23g, ?0.4mol) and N, N- dimethylformamide (260mL) were added into a 500mL reaction flask. Sodium tert-butoxide (35g, 0.36mol) was added slowly thereinto at 0Cand the reaction mixture was stirred at 0C for 1.5 hours. After completion of the reaction, the reaction mixture was poured into ice water slowly, and the precipitated solid was filtered to obtain the crude product. The filter cake was then washed with a lot of water and dried through air to obtain the title compound (yellow solid, 78g, 96%), which may be used directly for the subsequent reaction. (MS: [M+1] none)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16545-68-9, its application will become more common.
Reference:
Patent; Beijing Pearl Biotechnology Limited Liability Company; DONG, Jiaqiang; ZHONG, Boyu; YUAN, Hongbin; SHI, Quan; CHU, Shaosong; ZHANG, Deyi; ZHANG, Ruihao; (219 pag.)EP3150592; (2017); A1;,
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