Balaji, Sundarraman; Balamurugan, Gunasekaran; Ramesh, Rengan; Semeril, David published the artcile< Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3H)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide>, HPLC of Formula: 5344-90-1, the main research area is palladium benzoylhydrazone chelating complex preparation catalyst dehydrogenative coupling aminobenzamide; crystal structure palladium benzoylhydrazone chelating palladacycle complex; mol structure palladium benzoylhydrazone chelating palladacycle complex; quinazolinone preparation; benzyl alc dehydrogenative coupling reaction aminobenzamide palladium benzoylhydrazone catalyst.
A convenient protocol for the 1-pot synthesis of quinazolin-4(3H)-ones using Pd(II) complexes via dehydrogenative coupling of readily available benzyl alcs. and 2-aminobenzamide was described. New structurally related Pd(II) N^O chelating complexes of general configuration [Pd(L)Cl(PPh3)] (L = dimethylamino benzoylhydrazone ligands) were designed and synthesized. The formation of the complexes was recognized by anal. and spectral methods (FTIR, NMR, HR-MS). The presence of a square-planar geometry around the Pd(II) ion was confirmed by single crystal x-ray diffraction study. A wide range of substituted quinazolinones were successfully achieved from a diverse range of benzyl alcs. in good to excellent yields using 1.0 mol % of catalyst loading under aerobic conditions. Also, control experiments reveal that the dehydrogenative coupling reaction involves initially the formation of an aldehyde intermediate and subsequent formation of a cyclic aminal intermediate.
Organometallics published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, HPLC of Formula: 5344-90-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts