Saltiel, Jack; Krishnan, Sumesh B.; Gupta, Shipra; Hernberg, E. Aliea; Clark, Ronald J. published the artcile< Photochemistry and photophysics of cholesta-5,7,9(11)-trien-3β-ol: a fluorescent analogue of cholesterol>, Related Products of 434-16-2, the main research area is cholestatrienol fluorescent analog photochem photophysics; Cholestatrienol rearrangement; Endoperoxide phototoproducts; Fluorescence triplet yields.
Cholesta-5,7,9(11)-trien-3β-ol (9,11-dehydroprovitamin D3, CTL) is used as a fluorescent probe to track the presence and migration of cholesterol in vivo. CTL is known to be photochem. active, but little consideration has been given to the formation efficiency and possible toxicity of its photoproducts. In degassed THF (THF) solution, we isolated the photoproduct of CTL and of its 25-hydroxy derivative (HOCTL), and X-ray crystal structures were obtained for HOCTL and the photorearrangement product. The X-ray crystal structure and its 1H NMR spectrum confirm the product structure as a pentacyclic HOCTL isomer. In the presence of air in THF, endoperoxide formation via [2+4] addition of 1O2* across the B ring of CTL or HOCTL becomes the dominant photoreaction. The UV spectrum and decay kinetics of the triplet state of HOCTL, the precursor of 1O2*, are determined by transient absorption spectroscopy. We confirm the proposed structure of the endoperoxide by X-ray crystallog. Kinetics anal. of quantum yields provides rate constants for photophys. and photochem. events.
Photochemical & Photobiological Sciences published new progress about Crystal structure. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts